Novel combination of surgery and embolization reduces recurrence of subdural hematomas
· News-MedicalA novel combination of surgery and embolization used to treat subdural hematomas, bleeding between the brain and its protective membrane due to trauma, reduces the risk of follow-up surgeries, according to researchers at Weill Cornell Medicine and University at Buffalo. Embolization is a minimally invasive procedure that blocks specific blood vessels to stop abnormal bleeding.
The finding is based on EMBOLISE, a multi-center, randomized, clinical study that compared chronic subdural hematoma recurrence rates in patients treated with surgery and middle meningeal artery (MMA) embolization versus current standard of care with surgery alone.
The research, published Nov. 21 in the New England Journal of Medicine, found that hematoma recurrence or progression resulting in another surgery occurred in about 4% of patients who underwent MMA embolization plus surgery compared to more than 11% of those who received surgery alone.
Dr. Jason Davies, associate professor of neurosurgery in the Jacobs School of Medicine and Biomedical Sciences at University at Buffalo and study co-leadAlready quite common in older adults, by 2030 chronic subdural hematomas are expected to be the most common cranial neurosurgical disease in the world."
Need for better treatments
Symptoms of subdural hematoma-;including weakness, numbness, headaches, nausea, confusion or dizziness-;can come on slowly over days or weeks, after a fall or other head injury. "For the last century, doctors have treated symptomatic subdural hematomas the same way; with surgery to create a small hole in the skull or removing a small section of skull to drain the blood," Dr. Knopman said.
However, after a hematoma has been surgically drained, it recurs about 15% of the time, requiring another surgery and hospitalization. The hematoma recruits arterial blood vessels that keep it alive. "So even after you remove the blood, it can come back and require more surgery. This is particularly challenging for older patients, who are the most prevalent group suffering from chronic subdural hematomas," Dr. Knopman added.
"Considering chronic subdural hematomas are more likely to develop in people aged 60 and older, the need for treatment in our aging population is growing," Dr. Knopman said. Older adults are more at risk because head trauma from falls and blood thinning medication can contribute to bleeding.
EMBOLISE study suggests new standard of care
The EMBOLISE study was sponsored by Medtronic, which produces Onyx, the blood flow-blocking agent that was used in the treatment group of the study.
Hematoma recurrence or progression leading to another surgery within 90 days of the initial surgery occurred in approximately 4% of the treatment group compared to 11.3% of the control group. Serious adverse events attributed to MMA embolization occurred in 2% of patients who received it.
Dr. Knopman and his colleagues are now determining what role upfront MMA embolization could have in treating patients with chronic subdural hematomas that are not large enough for surgery. "If we embolize these patients early, we may decrease the number who need to be taken to surgery later," he said.
"In addition to demonstrating the role that the middle meningeal artery plays in the formation and recurrence of subdural hematomas, we have discovered an entirely new facet about the brain that has gone unknown and untreated for decades," he added.
Source: