Researchers develop novel oxygen-independent therapy for cancer

Tumors often contain areas of oxygen-deficient tissue that frequently withstand conventional therapies. This is because the drugs applied in tumors require oxygen to be effective. An international research team has developed a novel mechanism of action that works without oxygen: polymeric incorporated nanocatalysts target the tumor tissue selectively and switch off the glutathione that the cells need to survive. The group headed by Dr. Johannes Karges from the Faculty of Chemistry and Biochemistry at Ruhr University Bochum, Germany, published their findings in the journal Nature Communications on October 31, 2024.

Why tumors shrink but don’t disappear

Compound accumulates in tumor tissue

All cells of the body need and contain glutathione. However, the catalyst has a selective effect on cancer cells as it is packaged in polymeric nanoparticles that accumulate specifically in the tumor tissue. Experiments on cancer cells and on mice with human tumors, that were considered incurable, proved successful. "These are encouraging results that need to be confirmed in further studies," concludes Johannes Karges. "Still, there's a lot of research work to be done before it can be used in humans."

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Ruhr-University Bochum

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