Colorado vs. Baylor prediction, odds, line, spread: 2024 college football expert picks, top Deion Sanders bets

SportsLine expert Jimmie Kaylor revealed his CFB picks, predictions and props for the Baylor Bears vs. Colorado Buffaloes game featuring Shedeur Sanders and Travis Hunter

Deion Sanders and the Colorado Buffaloes (2-1) kick off a new era when they host the Baylor Bears at Folsom Field on Saturday. CU returned to the Big 12 after 13 seasons in Pac-12, and Saturday's matchup will be the program's first conference game since making the move. The Buffs aim to build off their 28-9 win over Colorado State in Week 3. Quarterback Shedeur Sanders and two-way star Travis Hunter were dominant in the win. Baylor is coming off an impressive 31-3 win over Air Force last week. The Bears lead the nation in passing defense, and have their sights set on returning to a bowl game in 2024 after finishing with a 3-9 record in 2023.

Kickoff in Boulder is scheduled for 8 p.m. ET. The Buffaloes are 2-point favorites in the latest Colorado vs. Baylor odds via SportsLine consensus, and the over/under is 51.5 points. Before making any Baylor vs. Colorado picks, you need to see the Week 4 college football predictions and betting advice from SportsLine's Jimmie Kaylor. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor destroyed the books in college football in 2023, netting a whopping 57.9 units while posting a 107-45-2 record. Anyone who followed his picks finished the season way up.

Now, Kaylor has dialed in on Colorado vs. Baylor on Saturday and just revealed his picks and predictions. You can head to SportsLine now to see his picks. Here are the college football odds and college football betting lines on the spread, money line, and over/under for Baylor vs. Colorado:

• Colorado vs. Baylor spread: Colorado -2
• Colorado vs. Baylor over/under: 51.5 points 
• Colorado vs. Baylor money line: Colorado -126, Baylor +105
• Colorado vs. Baylor picks: See picks at SportsLine

Why Colorado can cover

Baylor is coming off a hard-fought win over Air Force. Given the Falcons' style of play, it can often take opposing teams two or more weeks to completely recover physically, which could bode well for the Buffs. On top of that, teams that travel to Colorado have to deal with the altitude, which could come into play late in Saturday's game.

The Buffs also have a massive X-factor in cornerback/wide receiver Travis Hunter. The former five-star recruit is among the best players in the country at two completely separate positions, and he has the ability to single-handedly alter the trajectory of games. Hunter enters Saturday with 30 catches for 342 yards and five touchdowns on offense, and 11 tackles, two pass break-ups and an interception on defense. See which team to pick here.

Why Baylor can cover

In terms of overall matchups, Baylor has a lot working in its favor heading into Saturday. Colorado has attempted more passes than any other team in the country, and its offense is heavily reliant on getting the ball into the hands of Travis Hunter, Jimmy Horn Jr., LaJohntay Wester and Will Sheppard. The Bears currently have the best passing defense in the country, allowing only 75.7 yards per game through the air. Granted, one of Baylor's game's was against Air Force, but the Bears may have the best defense the Buffs have faced thus far. 

Offensively, the Bears are physical and have a punishing rushing attack. Running backs Dawson Pendergrass (30 carries, 144 yards, one touchdown) and Richard Reese (35 carries, 140 yards, one touchdown) lead the way for Baylor. On what could be a rainy night in Boulder, the Bears' advantage in the running game could pay dividends. See which team to pick here.

How to make Baylor vs. Colorado picks

Kaylor has analyzed Colorado vs. Colorado State from every angle and he's leaning Under on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

So who wins Colorado vs. Baylor on Saturday at Folsom Field in Boulder, and what critical X-factor makes one side of the spread a must back? Visit SportsLine now to see which side of the spread to jump on, all from the expert who profited $5,790 for $100 college football bettors in 2023, and find out.