A randomized trial of mexiletine and lamotrigine in adults with non-dystrophic myotonia
The study, published in Lancet Neurology, detailed the "head-to-head" trial implemented by the researchers to test two drugs, mexiletine and lamotrigine, on people with the condition.
Study reveals rising pharmaceutical industry sponsored clinical trials in the U.S.
Researchers at Fred Hutch Cancer Center identified a substantial increase over the past decade in the proportion of patients with cancer in the U.S. who participate in pharmaceutical industry sponsored clinical trials compared to those conducted with federal government support.
Novel approach combines glutaminase and HuR blockade to suppress breast cancer growth
A study led by Brazilian researchers and reported in an article published in the journal Nature Communications proposes that simultaneously targeting the enzyme glutaminase and the protein HuR, both of which are essential to tumor progression, may be effective in treating breast cancer.
Defective DNA repair mechanism linked to Huntington's disease progression
Researchers with McMaster University have discovered that the protein mutated in patients with Huntington's Disease doesn't repair DNA as intended, impacting the ability of brain cells to heal themselves.
Estrogen found to promote tumor growth in breast cancers without receptors
Estrogens are known to drive tumor growth in breast cancer cells that carry its receptors, but a new study by Duke Cancer Institute researchers unexpectedly finds that estrogens play a role in fueling the growth of breast cancers without the receptors, as well as numerous other cancers.
Disruption of circadian clock linked to accelerated colorectal cancer progression
Research from the University of California, Irvine has revealed how disruption of the circadian clock, the body's internal, 24-hour biological pacemaker, may accelerate the progression of colorectal cancer by affecting the gut microbiome and intestinal barrier function.
last updated on 28 Sep 04:16